Globe artichoke (Cynara scolymus L.) is a perennial plant belonging to Asteraceae family. It is one of the most suitable plants for growing organically. Artichoke has been used as choleretic. hepatoprotective, anticarcinogenic, antioxidant, antibacterial, antifungal, antimicrobial. cholesterol-reducing, and diuretic in traditional medicine. Artichoke has been cultivated worldwide because of its nutritional value and medicinal properties. In this study organically and conventionally grown artichokes were compared in terms of phenolic constituents, antibacterial and antioxidant activities. Artichoke leaves, bracts, and floral receptacles obtained from 2 different sources (organic and conventional) were freeze-dried, powdered, and extracts were prepared with methanol. Phenolic constituents (chlorogenic acid, cynarin, luteolin, and apigenin) were analysed by HPLC-DAD system. It was found that organic farming enhanced cynarin, chlorogenic acid, and luteolin amounts in receptacle (edible part). Organically grown leaves had also higher amounts of cynarin and chlorogenic acid than conventional ones. Cynarin amount was higher by 35% in organic receptacle and 20% in organic leaves. Organic farming also augmented the antioxidant property and flavonoid content of edible parts of the artichoke. Additionally, organically grown leaves had the highest antioxidant activity, total phenol and flavonoid contents. Antibacterial activity was observed with both organic and conventional leaves only against Staphylococcus epidermidis. ibis comparative study revealed that organic fanning enhanced the health-beneficial medicinal values of artichoke's heart and leaves.