Benzenin sıçan (Rat rattus Norvegicus) karaciğer ve kas dokusu glikojen seviyesine etkisi


Tezin Türü: Yüksek Lisans

Tezin Yürütüldüğü Kurum: Bursa Uludağ Üniversitesi, FEN-EDEBİYAT FAKÜLTESİ, BİYOLOJİ, Türkiye

Tezin Onay Tarihi: 2004

Tezin Dili: Türkçe

Öğrenci: FERDA ÖZDİKİCİOĞLU

Danışman: Egemen Dere

Özet:

In this study, 1 00 mg/kg of benzene - known as a toxic and carcinogenic agent commonly used in industry - was intraperitonally administered to Rat rattus norvegicus rats. 0, 2, 4, 8, 16, 32 and 64 hours later, its effects on the percentage of glycogen level on the animals' liver and muscle tissues and blood glucose level were examined. In the periods of experiment, an increase in the glycogen level in both muscles and liver depending on nutrition was observed in both control and experimental groups. However, due to the effect of benzene, noticeable increases and decreases in both tissues were observed. In the 64th hour, the differences occurring due to the effect of benzene disappeared. Increases and decreases in the blood glycogen level, observed in male and female animals, were not found rational except for some periods of experiment. The results prove that benzene affects the glycogen level in both liver and muscles. Key words: Benzene, Glycogen, Rat