The 7 nicotinic receptor dual allosteric agonist and positive allosteric modulator GAT107 reverses nociception in mouse models of inflammatory and neuropathic pain


Bagdas D., Wilkerson J. L. , Kulkarni A., Toma W., AlSharari S., Gul Z., ...More

BRITISH JOURNAL OF PHARMACOLOGY, vol.173, no.16, pp.2506-2520, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 173 Issue: 16
  • Publication Date: 2016
  • Doi Number: 10.1111/bph.13528
  • Title of Journal : BRITISH JOURNAL OF PHARMACOLOGY
  • Page Numbers: pp.2506-2520

Abstract

Background and PurposeOrthosteric agonists and positive allosteric modulators (PAMs) of the 7 nicotinic ACh receptor (nAChR) represent novel therapeutic approaches for pain modulation. Moreover, compounds with dual function as allosteric agonists and PAMs, known as ago-PAMs, add further regulation of receptor function.