The 7 nicotinic receptor dual allosteric agonist and positive allosteric modulator GAT107 reverses nociception in mouse models of inflammatory and neuropathic pain


Bagdas D., Wilkerson J. L., Kulkarni A., Toma W., AlSharari S., Gul Z., ...Daha Fazla

BRITISH JOURNAL OF PHARMACOLOGY, cilt.173, sa.16, ss.2506-2520, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 173 Sayı: 16
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1111/bph.13528
  • Dergi Adı: BRITISH JOURNAL OF PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2506-2520
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Background and PurposeOrthosteric agonists and positive allosteric modulators (PAMs) of the 7 nicotinic ACh receptor (nAChR) represent novel therapeutic approaches for pain modulation. Moreover, compounds with dual function as allosteric agonists and PAMs, known as ago-PAMs, add further regulation of receptor function.