The 7 nicotinic receptor dual allosteric agonist and positive allosteric modulator GAT107 reverses nociception in mouse models of inflammatory and neuropathic pain


Bagdas D., Wilkerson J. L., Kulkarni A., Toma W., AlSharari S., Gul Z., ...More

BRITISH JOURNAL OF PHARMACOLOGY, vol.173, no.16, pp.2506-2520, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 173 Issue: 16
  • Publication Date: 2016
  • Doi Number: 10.1111/bph.13528
  • Journal Name: BRITISH JOURNAL OF PHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2506-2520
  • Bursa Uludag University Affiliated: Yes

Abstract

Background and PurposeOrthosteric agonists and positive allosteric modulators (PAMs) of the 7 nicotinic ACh receptor (nAChR) represent novel therapeutic approaches for pain modulation. Moreover, compounds with dual function as allosteric agonists and PAMs, known as ago-PAMs, add further regulation of receptor function.