The 7 nicotinic receptor dual allosteric agonist and positive allosteric modulator GAT107 reverses nociception in mouse models of inflammatory and neuropathic pain

Bagdas, Deniz; Wilkerson, Jenny; Kulkarni, Abhijit; Toma, Wisam; AlSharari, Shakir; Gul, Zulfiye; Lichtman, Aron; Papke, Roger; Thakur, Ganesh; Damaj, M.

doi:10.1111/bph.13528

The 7 nicotinic receptor dual allosteric agonist and positive allosteric modulator GAT107 reverses nociception in mouse models of inflammatory and neuropathic pain

Atıf İçin Kopyala

Bagdas D., Wilkerson J. L., Kulkarni A., Toma W., AlSharari S., Gul Z., ...Daha Fazla

BRITISH JOURNAL OF PHARMACOLOGY, cilt.173, sa.16, ss.2506-2520, 2016 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 173 Sayı: 16
Basım Tarihi: 2016
Doi Numarası: 10.1111/bph.13528
Dergi Adı: BRITISH JOURNAL OF PHARMACOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.2506-2520
Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Background and PurposeOrthosteric agonists and positive allosteric modulators (PAMs) of the 7 nicotinic ACh receptor (nAChR) represent novel therapeutic approaches for pain modulation. Moreover, compounds with dual function as allosteric agonists and PAMs, known as ago-PAMs, add further regulation of receptor function.