The 7 nicotinic receptor dual allosteric agonist and positive allosteric modulator GAT107 reverses nociception in mouse models of inflammatory and neuropathic pain

Bagdas, Deniz; Wilkerson, Jenny; Kulkarni, Abhijit; Toma, Wisam; AlSharari, Shakir; Gul, Zulfiye; Lichtman, Aron; Papke, Roger; Thakur, Ganesh; Damaj, M.

doi:10.1111/bph.13528

The 7 nicotinic receptor dual allosteric agonist and positive allosteric modulator GAT107 reverses nociception in mouse models of inflammatory and neuropathic pain

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Bagdas D., Wilkerson J. L., Kulkarni A., Toma W., AlSharari S., Gul Z., ...More

BRITISH JOURNAL OF PHARMACOLOGY, vol.173, no.16, pp.2506-2520, 2016 (SCI-Expanded)

Publication Type: Article / Article
Volume: 173 Issue: 16
Publication Date: 2016
Doi Number: 10.1111/bph.13528
Journal Name: BRITISH JOURNAL OF PHARMACOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.2506-2520
Bursa Uludag University Affiliated: Yes

Abstract

Background and PurposeOrthosteric agonists and positive allosteric modulators (PAMs) of the 7 nicotinic ACh receptor (nAChR) represent novel therapeutic approaches for pain modulation. Moreover, compounds with dual function as allosteric agonists and PAMs, known as ago-PAMs, add further regulation of receptor function.