Overexpression of the Long Noncoding RNA HomeoboxA Transcript at the Distal Tip Predicts Poor Prognosis in a KRAS-Independent Manner in Periampullary Region Tumors


Balcin O., AKSOY S. , TUNCA B. , KAYA E. , EGELİ Ü. , Tezcan G. , ...More

PANCREAS, vol.47, no.2, pp.213-220, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 2
  • Publication Date: 2018
  • Doi Number: 10.1097/mpa.0000000000000984
  • Title of Journal : PANCREAS
  • Page Numbers: pp.213-220
  • Keywords: LncRNA, HOTTIP, KRAS, periampullary region tumors, prognosis, PANCREATIC DUCTAL ADENOCARCINOMA, CANCER, HOTTIP, HOTAIR, PROGRESSION, CHROMATIN, METASTASIS, EXPRESSION, BIOMARKERS, EVOLUTION

Abstract

Objectives: Periampullary region tumors (PRTs) are the fifth highest cause of cancer-related deaths worldwide. Although recent studies have highlighted the prognostic value of the long noncoding RNA HomeoboxA transcript at the distal tip (HOTTIP) in patients with pancreatic ductal adenocarcinoma, the relationship between HOTTIP and clinical outcome of all PRTs remains obscure. The aim of this study was to clarify the prognostic significance of HOTTIP in patients with all PRTs related to KRAS mutational status.