Overexpression of the Long Noncoding RNA HomeoboxA Transcript at the Distal Tip Predicts Poor Prognosis in a KRAS-Independent Manner in Periampullary Region Tumors

Balcin O., AKSOY S., TUNCA B., KAYA E., EGELİ Ü., Tezcan G., ...Daha Fazla

PANCREAS, cilt.47, sa.2, ss.213-220, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 2
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1097/mpa.0000000000000984
  • Dergi Adı: PANCREAS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.213-220
  • Anahtar Kelimeler: LncRNA, HOTTIP, KRAS, periampullary region tumors, prognosis, PANCREATIC DUCTAL ADENOCARCINOMA, CANCER, HOTTIP, HOTAIR, PROGRESSION, CHROMATIN, METASTASIS, EXPRESSION, BIOMARKERS, EVOLUTION
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Objectives: Periampullary region tumors (PRTs) are the fifth highest cause of cancer-related deaths worldwide. Although recent studies have highlighted the prognostic value of the long noncoding RNA HomeoboxA transcript at the distal tip (HOTTIP) in patients with pancreatic ductal adenocarcinoma, the relationship between HOTTIP and clinical outcome of all PRTs remains obscure. The aim of this study was to clarify the prognostic significance of HOTTIP in patients with all PRTs related to KRAS mutational status.