Lipoadenofection-mediated gene delivery to the corneal endothelium: prospects for modulating graft rejection.


Arancibia-Cárcamo C., Oral H. B. , Haskard D., Larkin D., George A.

Transplantation, vol.65, pp.62-7, 1998 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 65
  • Publication Date: 1998
  • Doi Number: 10.1097/00007890-199801150-00012
  • Title of Journal : Transplantation
  • Page Numbers: pp.62-7

Abstract

Background. Gene transfer to the corneal endothelium has potential for the prevention or reversal of corneal allograft rejection. Previous work has examined adenoviral vectors for gene transfer to endothelium, These have a number of theoretical and practical disadvantages, both for experimental and clinical applications. We have therefore used lipoadenofection, in which plasmid DNA is delivered using a combination of liposomes and adenovirus, to transfer marker genes to the cornea,