Lipoadenofection-mediated gene delivery to the corneal endothelium: prospects for modulating graft rejection.


Arancibia-Cárcamo C., Oral H. B., Haskard D., Larkin D., George A.

Transplantation, vol.65, pp.62-7, 1998 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 65
  • Publication Date: 1998
  • Doi Number: 10.1097/00007890-199801150-00012
  • Journal Name: Transplantation
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.62-7
  • Bursa Uludag University Affiliated: Yes

Abstract

Background. Gene transfer to the corneal endothelium has potential for the prevention or reversal of corneal allograft rejection. Previous work has examined adenoviral vectors for gene transfer to endothelium, These have a number of theoretical and practical disadvantages, both for experimental and clinical applications. We have therefore used lipoadenofection, in which plasmid DNA is delivered using a combination of liposomes and adenovirus, to transfer marker genes to the cornea,