Lipoadenofection-mediated gene delivery to the corneal endothelium: prospects for modulating graft rejection.

Arancibia-Cárcamo C., Oral H. B. , Haskard D., Larkin D., George A.

Transplantation, vol.65, pp.62-7, 1998 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 65
  • Publication Date: 1998
  • Doi Number: 10.1097/00007890-199801150-00012
  • Title of Journal : Transplantation
  • Page Numbers: pp.62-7


Background. Gene transfer to the corneal endothelium has potential for the prevention or reversal of corneal allograft rejection. Previous work has examined adenoviral vectors for gene transfer to endothelium, These have a number of theoretical and practical disadvantages, both for experimental and clinical applications. We have therefore used lipoadenofection, in which plasmid DNA is delivered using a combination of liposomes and adenovirus, to transfer marker genes to the cornea,