Palladium (II) Complex Enhances ROS-Dependent Apoptotic Effects via Autophagy Inhibition and Disruption of Multiple Signaling Pathways in Colorectal Cancer Cells

Aydinlik S., Erkisa M., Ari F., Celikler S., Ulukaya E.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, vol.21, no.6, pp.1284-1291, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 6
  • Publication Date: 2021
  • Doi Number: 10.2174/1871520620666200929153804
  • Journal Name: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Page Numbers: pp.1284-1291
  • Keywords: Apoptosis, autophagy, metal-based compounds, ROS, colorectal cancer, chloroquine, PLATINUM(II) SACCHARINATE COMPLEXES, COLON-CANCER, CYTOTOXIC ACTIVITY, IN-VITRO, 5-FLUOROURACIL, CHLOROQUINE, CHEMOTHERAPY, BEVACIZUMAB, COMBINATION, ACTIVATION
  • Bursa Uludag University Affiliated: Yes

Abstract

Background: Inhibition of autophagy is reported to be a therapeutically effective strategy in overcoming resistance that is a deadly outcome in cancer. One of the most common reasons for chemo-resistance to treatment is the patients with tumors exhibiting a KRAS mutation, which occurs in approximately 40% of colorectal cancer patients.