Impact of 3'UTR variation patterns of the KRAS gene on the aggressiveness of pancreatobiliary tumors with the KRAS G13D mutation in a Turkish population.


EGELİ Ü. , Ak S. , ÇEÇENER G. , TUNCA B. , Tezcan G. , Sevinc E. D. , ...More

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], vol.16, no.4, pp.677-86, 2016 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 4
  • Publication Date: 2016
  • Doi Number: 10.1016/j.pan.2016.05.004
  • Title of Journal : Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
  • Page Numbers: pp.677-86
  • Keywords: KRAS, 3' untranslated region, Codon 13, Mutation, Invasion, COLORECTAL-CANCER PATIENTS, K-RAS GENE, PANCREAS, ADENOCARCINOMA, CODON-12, POLYMORPHISM, EXPRESSION, CARCINOMA, P53, PROGRESSION

Abstract

Objective: Several studies have demonstrated the importance of mutations in codons 12, 13 and 61 and variations in the 3' untranslated region (3'UTR) of the ICRAS gene, frequently observed genetic events in the progression of pancreatobiliary tumors (PBT). However, limited data exist on the clinical effect of these alterations. The aim of the current study was to clarify the frequency of relevant alterations of the 3'UTR regions of the KRAS gene and the effect of KRAS 3'UTR polymorphisms on the prognosis of patients with codon 12, 13 and 61 mutations in a Turkish population with PBT.