Restorative effects of uridine plus docosahexaenoic acid in a rat model of Parkinson's disease


Cansev M. , Ulus I. H. , Wang L., Maher T. J. , Wurtman R. J.

Neuroscience Research, vol.62, no.3, pp.206-209, 2008 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 62 Issue: 3
  • Publication Date: 2008
  • Doi Number: 10.1016/j.neures.2008.07.005
  • Title of Journal : Neuroscience Research
  • Page Numbers: pp.206-209
  • Keywords: Parkinson's disease, Uridine, Docosahexaenoic acid, Dopamine, Tyrosine hydroxylase activity, Synapse, NEURITE OUTGROWTH, PARTIAL LESIONS, FATTY-ACIDS, BRAIN, DOPAMINE, SUPPLEMENTATION, RELEASE, GERBILS, OMEGA-3, SYSTEM

Abstract

Administering uridine-5′-monophosphate (UMP) and docosahexaenoic acid (DHA) increases synaptic membranes (as characterized by pre- and post-synaptic proteins) and dendritic spines in rodents. We examined their effects on rotational behavior and dopaminergic markers in rats with partial unilateral 6-hydroxydopamine (6-OHDA)-induced striatal lesions. Rats receiving UMP, DHA, both, or neither, daily, and intrastriatal 6-OHDA 3 days after treatment onset, were tested for d-amphetamine-induced rotational behavior and dopaminergic markers after 24 and 28 days, respectively. UMP/DHA treatment reduced ipsilateral rotations by 57% and significantly elevated striatal dopamine, tyrosine hydroxylase (TH) activity, TH protein and synapsin-1 on the lesioned side. Hence, giving uridine and DHA may partially restore dopaminergic neurotransmission in this model of Parkinson's disease. © 2008 Elsevier Ireland Ltd and the Japan Neuroscience Society.