A Novel Spirometric Measure Identifies Mild COPD Unidentified by Standard Criteria

Dilektasli A. G. , Porszasz J., Casaburi R., Stringer W. W. , Bhatt S. P. , Pak Y., ...More

CHEST, vol.150, no.5, pp.1080-1090, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 150 Issue: 5
  • Publication Date: 2016
  • Doi Number: 10.1016/j.chest.2016.06.047
  • Title of Journal : CHEST
  • Page Numbers: pp.1080-1090


BACKGROUND: In chronic obstructive pulmonary disease, both smaller and larger airways are affected. FEV1 mainly reflects large airways obstruction, while the later fraction of forced exhalation reflects reduction in terminal expiratory flow. In this study, the objective was to evaluate the relationship between spirometric ratios, including the ratio of forced expiratory volume in 3 and 6 seconds (FEV3/FEV6), and small airways measures and gas trapping at quantitative chest CT scanning, and clinical outcomes in the Genetic Epidemiology of COPD (COPDGene) cohort.