A Novel Spirometric Measure Identifies Mild COPD Unidentified by Standard Criteria


Dilektasli A. G., Porszasz J., Casaburi R., Stringer W. W., Bhatt S. P., Pak Y., ...Daha Fazla

CHEST, cilt.150, sa.5, ss.1080-1090, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 150 Sayı: 5
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.chest.2016.06.047
  • Dergi Adı: CHEST
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1080-1090
  • Bursa Uludağ Üniversitesi Adresli: Hayır

Özet

BACKGROUND: In chronic obstructive pulmonary disease, both smaller and larger airways are affected. FEV1 mainly reflects large airways obstruction, while the later fraction of forced exhalation reflects reduction in terminal expiratory flow. In this study, the objective was to evaluate the relationship between spirometric ratios, including the ratio of forced expiratory volume in 3 and 6 seconds (FEV3/FEV6), and small airways measures and gas trapping at quantitative chest CT scanning, and clinical outcomes in the Genetic Epidemiology of COPD (COPDGene) cohort.