In this study, comfort and moisture transmission properties of fine shirting fabrics produced by combining widely used fibre types of viscose, PES and cotton with acrylic fiber were investigated. For this purpose, 10 different fabrics were woven with viscose warp and cotton, PES, viscose, acrylic, cotton/acrylic, viscose/acrylic, and PES/acrylic weft yarns and with plain and etamine weaves. Thermal resistance, thermal conductivity, thermal absorbtivity, air permeability and moisture transmission properties of fabrics were measured and the results then evaluated statistically. According to the results obtained, thermal resistance, thermal conductivity, thermal absorbtivity and air permeability properties of fabrics were not affected by material type and addition of acrylic yarns, but weaving type showed a significant effect on these fabric properties. It was also seen that material type and acrylic yarn usage in the fabrics influenced moisture management properties of fabrics and increased OMMC values.