The mediation of central cyclooxygenase and lipoxygenase pathways in orexin-induced cardiovascular effects

Altinbas B., Guvenc-Bayram G., YALÇIN M.

BRAIN RESEARCH, vol.1754, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 1754
  • Publication Date: 2021
  • Doi Number: 10.1016/j.brainres.2020.147239
  • Journal Name: BRAIN RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Animal Behavior Abstracts, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, Linguistics & Language Behavior Abstracts, MEDLINE, Psycinfo, Veterinary Science Database
  • Keywords: Orexin, Cylooygenase and lipoxygenase pathways, Cardiovascular parameters, Intracerebroventricular, Microdialysis, Posterior hypothalamus, ROSTRAL VENTROLATERAL MEDULLA, PHOSPHOLIPASE A(2) ACTIVATOR, CENTRAL HISTAMINERGIC SYSTEM, ARACHIDONIC-ACID, ARTERIAL-PRESSURE, INJECTED MELITTIN, HYPOTENSIVE RATS, THROMBOXANE A(2), HEART-RATE, NEURONS
  • Bursa Uludag University Affiliated: Yes


Previously it was reported that central orexin (OX) and arachidonic acid (AA) signaling pathways played an active role in the control of the cardiovascular system. It was also reported that they have exhibited their cardiovascular control role by using similar central or peripheral mechanisms. However, there has been no study demonstrating the interaction between OX and AA signaling pathways in terms of cardiovascular control. The current study was designed to investigate the possible mediation of the central cyclooxygenase (COX) and lipoxygenase (LOX) pathways in OX-induced cardiovascular effects in the rats.