JOURNAL OF SURGICAL RESEARCH, vol.183, no.1, pp.119-128, 2013 (Journal Indexed in SCI)
Article / Article
Title of Journal :
JOURNAL OF SURGICAL RESEARCH
Necrotizing enterocolitis, CDP-choline, Neonatal rat, Inflammation, Apoptosis, ULCERATIVE-COLITIS, INFLAMMATORY RESPONSE, ISCHEMIA-REPERFUSION, MUCUS BARRIER, PHOSPHATIDYLCHOLINE, CYTIDINE, APOPTOSIS, MECHANISMS, CITICOLINE, NECROSIS
Background: Cytidine 5'-diphosphocholine (CDP-choline) is an endogenous intermediate in the biosynthesis of phosphatidylcholine, a contributor to the mucosal defense of the intestine. The aim of this study was to evaluate the possible cytoprotective effect of CDP-choline treatment on intestinal cell damage, membrane phospholipid content, inflammation, and apoptosis in a neonatal rat model of necrotizing enterocolitis (NEC).