CDP-choline reduces severity of intestinal injury in a neonatal rat model of necrotizing enterocolitis

Cetinkaya M., CANSEV M., Cekmez F., Tayman C., Canpolat F. E., KAFA İ. M., ...Daha Fazla

JOURNAL OF SURGICAL RESEARCH, cilt.183, sa.1, ss.119-128, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 183 Sayı: 1
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.jss.2012.11.032
  • Dergi Adı: JOURNAL OF SURGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.119-128
  • Anahtar Kelimeler: Necrotizing enterocolitis, CDP-choline, Neonatal rat, Inflammation, Apoptosis, ULCERATIVE-COLITIS, INFLAMMATORY RESPONSE, ISCHEMIA-REPERFUSION, MUCUS BARRIER, PHOSPHATIDYLCHOLINE, CYTIDINE, APOPTOSIS, MECHANISMS, CITICOLINE, NECROSIS
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Background: Cytidine 5'-diphosphocholine (CDP-choline) is an endogenous intermediate in the biosynthesis of phosphatidylcholine, a contributor to the mucosal defense of the intestine. The aim of this study was to evaluate the possible cytoprotective effect of CDP-choline treatment on intestinal cell damage, membrane phospholipid content, inflammation, and apoptosis in a neonatal rat model of necrotizing enterocolitis (NEC).