CDP-choline reduces severity of intestinal injury in a neonatal rat model of necrotizing enterocolitis


Cetinkaya M., CANSEV M. , Cekmez F., Tayman C., Canpolat F. E. , KAFA İ. M. , ...More

JOURNAL OF SURGICAL RESEARCH, vol.183, no.1, pp.119-128, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 183 Issue: 1
  • Publication Date: 2013
  • Doi Number: 10.1016/j.jss.2012.11.032
  • Title of Journal : JOURNAL OF SURGICAL RESEARCH
  • Page Numbers: pp.119-128
  • Keywords: Necrotizing enterocolitis, CDP-choline, Neonatal rat, Inflammation, Apoptosis, ULCERATIVE-COLITIS, INFLAMMATORY RESPONSE, ISCHEMIA-REPERFUSION, MUCUS BARRIER, PHOSPHATIDYLCHOLINE, CYTIDINE, APOPTOSIS, MECHANISMS, CITICOLINE, NECROSIS

Abstract

Background: Cytidine 5'-diphosphocholine (CDP-choline) is an endogenous intermediate in the biosynthesis of phosphatidylcholine, a contributor to the mucosal defense of the intestine. The aim of this study was to evaluate the possible cytoprotective effect of CDP-choline treatment on intestinal cell damage, membrane phospholipid content, inflammation, and apoptosis in a neonatal rat model of necrotizing enterocolitis (NEC).