Familial Mediterranean fever gene mutations as a risk factor for early coronary artery disease


Basar N., Kisacik B., Ercan S., Pehlivan Y. , Yilmaz S., Simsek I., ...More

INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, vol.20, no.12, pp.2113-2117, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 12
  • Publication Date: 2017
  • Doi Number: 10.1111/1756-185x.12356
  • Title of Journal : INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
  • Page Numbers: pp.2113-2117

Abstract

ObjectiveCardiovascular diseases (CVD) are very common in the general population. Atherosclerosis is the main pathogenesis. Familial Mediterranean fever (FMF) is an autosomal recessive disease. The gene causing FMF, designated MEFV, encodes a protein called pyrin or marenostrin that is expressed mainly in myeloid bone marrow precursors, neutrophils and monocytes. We herein aimed to determine the prevalence of MEFV mutations (all exon 2, 10 mutations) in patients with early coronary heart disease (early CHD) and coronary heart disease (CHD) with multiple risk factors and among the healthy subjects as controls.