Familial Mediterranean fever gene mutations as a risk factor for early coronary artery disease

Basar, Nurcan; Kisacik, Bunyamin; Ercan, Suleyman; Pehlivan, YAVUZ; Yilmaz, Sedat; Simsek, Ismail; Erdem, Hakan; Ozer, Orhan; Pay, Salih; Onat, Ahmet; Dinc, Ayhan

doi:10.1111/1756-185x.12356

Familial Mediterranean fever gene mutations as a risk factor for early coronary artery disease

Basar N., Kisacik B., Ercan S., Pehlivan Y., Yilmaz S., Simsek I., ...Daha Fazla

INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, cilt.20, sa.12, ss.2113-2117, 2017 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 20 Sayı: 12
Basım Tarihi: 2017
Doi Numarası: 10.1111/1756-185x.12356
Dergi Adı: INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.2113-2117
Bursa Uludağ Üniversitesi Adresli: Evet

Özet

ObjectiveCardiovascular diseases (CVD) are very common in the general population. Atherosclerosis is the main pathogenesis. Familial Mediterranean fever (FMF) is an autosomal recessive disease. The gene causing FMF, designated MEFV, encodes a protein called pyrin or marenostrin that is expressed mainly in myeloid bone marrow precursors, neutrophils and monocytes. We herein aimed to determine the prevalence of MEFV mutations (all exon 2, 10 mutations) in patients with early coronary heart disease (early CHD) and coronary heart disease (CHD) with multiple risk factors and among the healthy subjects as controls.