N-alkyl imidazole-based homonuclear coordination complex as a neutral organocatalyst for the faster and efficient construction of 3,4-dihydro-2H-1,3-oxazine scaffold


YILDIRIM A. , Goker M.

APPLIED ORGANOMETALLIC CHEMISTRY, vol.35, no.12, 2021 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 12
  • Publication Date: 2021
  • Doi Number: 10.1002/aoc.6425
  • Title of Journal : APPLIED ORGANOMETALLIC CHEMISTRY
  • Keywords: 1, 3-benzoxazines, metal complex catalyst, multicomponent synthesis, N-alkylimidazole, two-component synthesis, BENZOXAZINE, DERIVATIVES, CHAIN, CO2

Abstract

In the present work, homonuclear coordination complex including Zn (II) and N-hexadecylimidazole ligand was used for the first time as a highly efficient homogeneous neutral organocatalyst for the synthesis of 3,4-dihydro-2H-1,3-benzoxazine monomers. Therefore, N-alkyl or N-aryl substituted, both mono-benzoxazine and bis-benzoxazine, were successfully synthesized (21 examples) via Mannich-type condensation reactions. Effortlessly obtaining the pure product with high yields and the short reaction time makes this method more useful and advantageous than the common existing benzoxazine synthesis methods.