This study describes a salmonella infection in a chinchilla farm of 40 families in the Yalova region. Twenty-four families were affected in a 10-day period after the outbreak of the disease and the clinical signs were apathy, anorexia, diarrhoea with or without hemorrhage, tremors, local paralysis, mucopurulent or hemorrhagic vaginal secretion in some females, abortions in 1 to 2 month-pregnant animals and death. The newborn and pregnant animals were affected more severely. Two live chinchillas with clinical signs were euthanized and gross pathological, histopathological and microbiological examinations were performed. In the gross and microscopical examinations, the most severe lesions were due to enteritis together with findings suggestive of septicemia. Inflammation of the uterus with slightly hemorrhagic, mucopurulent exudate was also seen. Isolation and identification of Salmonella enteritidis and S, typhimurium were carried out during the microbiological examination of the sampled tissues. The isolated Salmonella strains were found to be sensitive to enrofloxacin, amoxycillin and gentamicin, and resistant to erythromycin and ampicillin.