Successful Treatment of Central Nervous System Involvement in Posttransplant EBV-related Lymphoproliferative Disease With Intrathecal Rituximab Therapy.

Aslan F., Güler S., Sezgin Evim M., Aslier M., Yazici Z., Öztürk Nazlioğlu H., ...More

Journal of pediatric hematology/oncology, vol.45, no.5, 2023 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 5
  • Publication Date: 2023
  • Doi Number: 10.1097/mph.0000000000002592
  • Journal Name: Journal of pediatric hematology/oncology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, MEDLINE
  • Keywords: CNS involvement, PTLD, HSCT, intrathecal rituximab, STEM-CELL TRANSPLANTATION, CNS
  • Bursa Uludag University Affiliated: Yes

Abstract

The posttransplant lymphoproliferative disease is a severe cause of morbidity and mortality following allogeneic hematopoietic stem cell transplantation. Central Nervous System involvement in EBV-related PTLD is rare, and there is no standard treatment recommendation. We present our patient and discuss other previously reported cases of EBV-associated PTLD with CNS involvement.