HER-2 positivity rate in dogs with mammary carcinoma: a systematic review and meta-analysis


Uzabaci E., Ozyigit M. Ö. , Ercan I., Arda O.

JOURNAL OF THE HELLENIC VETERINARY MEDICAL SOCIETY, vol.71, no.2, pp.2141-2148, 2020 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Review
  • Volume: 71 Issue: 2
  • Publication Date: 2020
  • Title of Journal : JOURNAL OF THE HELLENIC VETERINARY MEDICAL SOCIETY
  • Page Numbers: pp.2141-2148
  • Keywords: HER-2, meta-analysis, canine, mammary tumor, HUMAN-BREAST, IN-SITU, EXPRESSION, TUMORS, EGFR, OVEREXPRESSION, PHENOTYPE, ONCOGENE, ESTROGEN

Abstract

Human epidermal growth factor receptor 2 (HER-2) plays an essential role in cell growth and survival. HER-2 overexpression occurs in 20-30% of human breast tumors and has prognostic value as it is associated with disease progression. HER-2 overexpression is also associated with tumor progression and metastasis in malignant mammary tumors of the canine. However, in the literature, different positivity classifications/scoring were used in the evaluation of HER-2 status, and there is no consensus in terms of scoring of HER-2 expression in canine mammary tumors. In this study, it was aimed to estimate the HER-2 positivity rate by evaluating the results of the study using different positivity classifications by meta-analysis. In this context, by using "HER-2 canine mammary tumor" keywords, Pubmed and Web of Science electronic databases were scanned until February 2019, and a total of 97 related studies were found. However, 20 of these studies were used for the analysis. Two different meta-analyses were performed to evaluate the HER-2 positivity status with "2+ and 3+" and "3+" scores. As a result, HER-2 positivity rates were determined at 25.87% and 25.99% for the studies using "2+/3+" scores and "3+" respectively for HER-2 positivity. Therefore, this result suggests that the rate of HER-2 positivity is similar between humans and dogs.