The association between the chromosome 9p21 CDKN2B-AS1 gene variants and the lipid metabolism: A pre-diagnostic biomarker for coronary artery disease

TEMEL Ş. G., Ergoren M. C.

ANATOLIAN JOURNAL OF CARDIOLOGY, cilt.21, sa.1, ss.31-38, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 1
  • Basım Tarihi: 2019
  • Doi Numarası: 10.14744/anatoljcardiol.2018.90907
  • Dergi Adı: ANATOLIAN JOURNAL OF CARDIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.31-38
  • Anahtar Kelimeler: chr9p21, rs4977574, rs1333040, biomarkers, coronary artery disease, GENOME-WIDE ASSOCIATION, MYOCARDIAL-INFARCTION, CARDIOVASCULAR-DISEASE, LOCUS, POLYMORPHISMS, POPULATION, RS4977574, RISK, SNPS, ATHEROSCLEROSIS
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Objective: Recent genome-wide association studies have established that polymorphisms within CDKN2B-ASI of chr9p21.3 locus increased susceptibility to coronary artery disease (CAD) or myocardial infarction. Common variants of CDKN2B-AS1 (including rs4977574 A>G and rs1333040 C>T) are determined to be directly associated with CADs in many populations worldwide and suggested biomarkers for the early detection of CAD. There is a lack of investigation for the association between CDKN2B-AS1 rs4977574 A>G and rs1333040 C>T genetic modifiers and CAD in a Turkish Cypriot population. The aim of the present study was to investigate the potential effects of these variants on susceptibility to developing CAD in a Turkish Cypriot population and their contribution to lipid metabolism.