TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.43, no.2, pp.101-109, 2018 (SCI-Expanded)
Article / Article
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
PARP inhibitor, PARylation, Bosutinib, Multi-kinase inhibitor, Chemosensitizer, POLY(ADP-RIBOSE) POLYMERASE-1 INHIBITOR, SKI-606 BOSUTINIB, BREAST-CANCER, GROWTH, DEATH, ACTIVATION, PROSTATE, INVASION, PATHWAY, STRESS
Bursa Uludag University Affiliated:
Background: Poly(ADP-ribosyl)ation (PARylation) catalyzed mainly by PARP1 is a highly regulated posttranslational modification associated with several pathways in cellular physiology and genotoxic deoxyribonucleic acid (DNA) damage response. PAR polymers and PARP enzyme function in DNA integrity maintenance and several PARP inhibitors have entered clinical phase studies for cancer therapies.