TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.43, no.2, pp.101-109, 2018 (Journal Indexed in SCI)
Article / Article
Title of Journal :
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
PARP inhibitor, PARylation, Bosutinib, Multi-kinase inhibitor, Chemosensitizer, POLY(ADP-RIBOSE) POLYMERASE-1 INHIBITOR, SKI-606 BOSUTINIB, BREAST-CANCER, GROWTH, DEATH, ACTIVATION, PROSTATE, INVASION, PATHWAY, STRESS
Background: Poly(ADP-ribosyl)ation (PARylation) catalyzed mainly by PARP1 is a highly regulated posttranslational modification associated with several pathways in cellular physiology and genotoxic deoxyribonucleic acid (DNA) damage response. PAR polymers and PARP enzyme function in DNA integrity maintenance and several PARP inhibitors have entered clinical phase studies for cancer therapies.