Enhancement of tendon-bone healing of anterior cruciate ligament grafts by blockage of matrix metalloproteinases

Demirag B., Sarisozen B., Ozer O., Kaplan T., Ozturk C.

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, no.11, pp.2401-2410, 2005 (SCI-Expanded) identifier identifier identifier


Background: The use of soft-tissue grafts for anterior cruciate ligament reconstruction delays the healing process. This delay may be due to biochemical and/or biomechanical insults. We hypothesized that the blocking effect of alpha(2)-macroglobulin on synovial matrix metalloproteinase activity may enhance the healing of tendon graft in a bone tunnel.