Enhancement of tendon-bone healing of anterior cruciate ligament grafts by blockage of matrix metalloproteinases

Demirag, B; Sarisozen, MEHMET; Ozer, O; Kaplan, T; Ozturk, C

doi:10.2106/jbjs.d.01952

Enhancement of tendon-bone healing of anterior cruciate ligament grafts by blockage of matrix metalloproteinases

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Demirag B., Sarisozen B., Ozer O., Kaplan T., Ozturk C.

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, no.11, pp.2401-2410, 2005 (SCI-Expanded)

Publication Type: Article / Article
Volume: Issue: 11
Publication Date: 2005
Doi Number: 10.2106/jbjs.d.01952
Journal Name: JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.2401-2410
Bursa Uludag University Affiliated: Yes

Abstract

Background: The use of soft-tissue grafts for anterior cruciate ligament reconstruction delays the healing process. This delay may be due to biochemical and/or biomechanical insults. We hypothesized that the blocking effect of alpha(2)-macroglobulin on synovial matrix metalloproteinase activity may enhance the healing of tendon graft in a bone tunnel.