Enhancement of tendon-bone healing of anterior cruciate ligament grafts by blockage of matrix metalloproteinases

Demirag, B; Sarisozen, MEHMET; Ozer, O; Kaplan, T; Ozturk, C

doi:10.2106/jbjs.d.01952

Enhancement of tendon-bone healing of anterior cruciate ligament grafts by blockage of matrix metalloproteinases

Demirag B., Sarisozen B., Ozer O., Kaplan T., Ozturk C.

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, sa.11, ss.2401-2410, 2005 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: Sayı: 11
Basım Tarihi: 2005
Doi Numarası: 10.2106/jbjs.d.01952
Dergi Adı: JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.2401-2410
Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Background: The use of soft-tissue grafts for anterior cruciate ligament reconstruction delays the healing process. This delay may be due to biochemical and/or biomechanical insults. We hypothesized that the blocking effect of alpha(2)-macroglobulin on synovial matrix metalloproteinase activity may enhance the healing of tendon graft in a bone tunnel.