Enhancement of tendon-bone healing of anterior cruciate ligament grafts by blockage of matrix metalloproteinases


Demirag B., Sarisozen B., Ozer O., Kaplan T., Ozturk C.

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, sa.11, ss.2401-2410, 2005 (SCI-Expanded) identifier identifier identifier

Özet

Background: The use of soft-tissue grafts for anterior cruciate ligament reconstruction delays the healing process. This delay may be due to biochemical and/or biomechanical insults. We hypothesized that the blocking effect of alpha(2)-macroglobulin on synovial matrix metalloproteinase activity may enhance the healing of tendon graft in a bone tunnel.