Enhancement of tendon-bone healing of anterior cruciate ligament grafts by blockage of matrix metalloproteinases


Demirag B., Sarisozen B. , Ozer O., Kaplan T., Ozturk C.

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, no.11, pp.2401-2410, 2005 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: Issue: 11
  • Publication Date: 2005
  • Doi Number: 10.2106/jbjs.d.01952
  • Title of Journal : JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
  • Page Numbers: pp.2401-2410

Abstract

Background: The use of soft-tissue grafts for anterior cruciate ligament reconstruction delays the healing process. This delay may be due to biochemical and/or biomechanical insults. We hypothesized that the blocking effect of alpha(2)-macroglobulin on synovial matrix metalloproteinase activity may enhance the healing of tendon graft in a bone tunnel.