Cytochrome c oxidase is activated by the oncoprotein Ras and is required for A549 lung adenocarcinoma growth

Telang S., Nelson K. K., Siow D. L., YALÇIN A., Thornburg J. M., Imbert-Fernandez Y., ...Daha Fazla

MOLECULAR CANCER, cilt.11, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1186/1476-4598-11-60
  • Dergi Adı: MOLECULAR CANCER
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Mitochondria, Glycolysis, Tricarboxylic acid cycle, Electron transport chain, Oncogene, MITOCHONDRIAL METABOLISM, PROSTATE-CANCER, SUBUNITS, OXYGEN, CELLS, TRANSFORMATION, EXPRESSION, INCREASES, ONCOGENE, PROTEOME
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Background: Constitutive activation of Ras in immortalized bronchial epithelial cells increases electron transport chain activity, oxygen consumption and tricarboxylic acid cycling through unknown mechanisms. We hypothesized that members of the Ras family may stimulate respiration by enhancing the expression of the Vb regulatory subunit of cytochrome c oxidase (COX).