Cytochrome c oxidase is activated by the oncoprotein Ras and is required for A549 lung adenocarcinoma growth

Telang S., Nelson K. K. , Siow D. L. , YALÇIN A. , Thornburg J. M. , Imbert-Fernandez Y., ...More

MOLECULAR CANCER, vol.11, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 11
  • Publication Date: 2012
  • Doi Number: 10.1186/1476-4598-11-60
  • Title of Journal : MOLECULAR CANCER
  • Keywords: Mitochondria, Glycolysis, Tricarboxylic acid cycle, Electron transport chain, Oncogene, MITOCHONDRIAL METABOLISM, PROSTATE-CANCER, SUBUNITS, OXYGEN, CELLS, TRANSFORMATION, EXPRESSION, INCREASES, ONCOGENE, PROTEOME

Abstract

Background: Constitutive activation of Ras in immortalized bronchial epithelial cells increases electron transport chain activity, oxygen consumption and tricarboxylic acid cycling through unknown mechanisms. We hypothesized that members of the Ras family may stimulate respiration by enhancing the expression of the Vb regulatory subunit of cytochrome c oxidase (COX).