Thiol/Disulfide Homeostasis in Bipolar and Unipolar Depression

Erzin G., ÖZKAYA G. , Topcuoglu C., Yuksel R. N. , Erel O., Yurt E. F. , ...More

CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE, vol.18, no.3, pp.395-401, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 3
  • Publication Date: 2020
  • Doi Number: 10.9758/cpn.2020.18.3.395
  • Title of Journal : CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
  • Page Numbers: pp.395-401
  • Keywords: Oxidative stress, Bipolar depression, Unipolar depression, Mood disorder, OXIDATIVE STRESS MARKER, LIPID-PEROXIDATION, REDOX SYSTEMS, RATING-SCALE, RELIABILITY, GLUTATHIONE, METABOLISM, OLANZAPINE, DISORDER, VALIDITY

Abstract

Objective: Bipolar disorder and unipolar depressive disorder are complex phenotypes. There appear to be phenotypical, mechanistic, and therapeutic differences between bipolar depression (BD) and unipolar depression (UD). There is a need for understanding the underlying biological variation between these clinical entities. The role of oxidative processes underlying bipolar disorder and depression has been demonstrated. Thiol-disulfide homeostasis (TDH) is a recent oxidative stress marker. In this study, we aimed to inspect patients with bipolar depression and unipolar depression in terms of thiol-disulfide balance and to compare them with healthy controls.