Thiol/Disulfide Homeostasis in Bipolar and Unipolar Depression

Erzin G., ÖZKAYA G., Topcuoglu C., Yuksel R. N., Erel O., Yurt E. F., ...Daha Fazla

CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE, cilt.18, sa.3, ss.395-401, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 3
  • Basım Tarihi: 2020
  • Doi Numarası: 10.9758/cpn.2020.18.3.395
  • Dergi Adı: CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, EMBASE, Psycinfo
  • Sayfa Sayıları: ss.395-401
  • Anahtar Kelimeler: Oxidative stress, Bipolar depression, Unipolar depression, Mood disorder, OXIDATIVE STRESS MARKER, LIPID-PEROXIDATION, REDOX SYSTEMS, RATING-SCALE, RELIABILITY, GLUTATHIONE, METABOLISM, OLANZAPINE, DISORDER, VALIDITY
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Objective: Bipolar disorder and unipolar depressive disorder are complex phenotypes. There appear to be phenotypical, mechanistic, and therapeutic differences between bipolar depression (BD) and unipolar depression (UD). There is a need for understanding the underlying biological variation between these clinical entities. The role of oxidative processes underlying bipolar disorder and depression has been demonstrated. Thiol-disulfide homeostasis (TDH) is a recent oxidative stress marker. In this study, we aimed to inspect patients with bipolar depression and unipolar depression in terms of thiol-disulfide balance and to compare them with healthy controls.