The role of immunohistochemical adrenomedullin and Bcl-2 expression in development of type-1 endometrial adenocarcinoma Adrenomedullin expression in endometrium

BOZKURT K. K., Yalcin Y., Erdemoglu E., Tatar B., ERDEMOĞLU E., Cerci S. S., ...More

PATHOLOGY RESEARCH AND PRACTICE, vol.212, no.5, pp.450-455, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 212 Issue: 5
  • Publication Date: 2016
  • Doi Number: 10.1016/j.prp.2016.02.021
  • Journal Name: PATHOLOGY RESEARCH AND PRACTICE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.450-455
  • Bursa Uludag University Affiliated: No

Abstract

Background: Adrenomedullin (AM) is a pluripotent peptide first discovered from human pheochromocytoma. AM expression has been shown in various cancer types including endometrium cancer. Bcl-2 is an antiapoptotic protein which might be regulated by AM in hypoxic conditions. The aim of the present study was to investigate the role of AM and Bcl-2 expressions in carcinogenesis of type-1 endometrium cancer.