The role of immunohistochemical adrenomedullin and Bcl-2 expression in development of type-1 endometrial adenocarcinoma Adrenomedullin expression in endometrium

BOZKURT K. K., Yalcin Y., Erdemoglu E., Tatar B., ERDEMOĞLU E., Cerci S. S., ...Daha Fazla

PATHOLOGY RESEARCH AND PRACTICE, cilt.212, sa.5, ss.450-455, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 212 Sayı: 5
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.prp.2016.02.021
  • Dergi Adı: PATHOLOGY RESEARCH AND PRACTICE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.450-455
  • Bursa Uludağ Üniversitesi Adresli: Hayır

Özet

Background: Adrenomedullin (AM) is a pluripotent peptide first discovered from human pheochromocytoma. AM expression has been shown in various cancer types including endometrium cancer. Bcl-2 is an antiapoptotic protein which might be regulated by AM in hypoxic conditions. The aim of the present study was to investigate the role of AM and Bcl-2 expressions in carcinogenesis of type-1 endometrium cancer.