Healthcare-associated Gram-negative bloodstream infections: antibiotic resistance and predictors of mortality

Ergonul O., Aydin M., Azap A., Basaran S., Tekin S., Kaya S., ...More

JOURNAL OF HOSPITAL INFECTION, vol.94, no.4, pp.381-385, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 94 Issue: 4
  • Publication Date: 2016
  • Doi Number: 10.1016/j.jhin.2016.08.012
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.381-385
  • Keywords: Bloodstream, Gram-negative, Healthcare, IMPACT, ENTEROBACTERIACEAE, EPIDEMIOLOGY, BACTEREMIA, OUTCOMES
  • Bursa Uludag University Affiliated: Yes


This article describes the prevalence of antibiotic resistance and predictors of mortality for healthcare-associated (HA) Gram-negative bloodstream infections (GN-BSI). In total, 831 cases of HA GN-BSI from 17 intensive care units in different centres in Turkey were included; the all-cause mortality rate was 44%. Carbapenem resistance in Klebsiella pneumoniae was 38%, and the colistin resistance rate was 6%. Multi-variate analysis showed that age > 70 years [odds ratio (OR) 2, 95% confidence interval (CI) 1.22-3.51], central venous catheter use (OR 2.1, 95% CI 1.09-4.07), ventilator- associated pneumonia (OR 1.9, 95% CI 1.1-3.16), carbapenem resistance (OR 1.8, 95% CI 1.11-2.95) and APACHE II score (OR 1.1, 95% CI 1.07-1.13) were significantly associated with mortality. (C) 2016 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.