The role of immunohistochemical staining with CK7 in the differential diagnosis of autoimmune hepatitis

Ozsen M., Adim S. B., Akyildiz E. U., Gurel S.

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, vol.120, no.11, pp.839-842, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 120 Issue: 11
  • Publication Date: 2019
  • Doi Number: 10.4149/bll_2019_139
  • Journal Name: BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.839-842
  • Keywords: CK7, ductular hepatocyte, autoimmune hepatitis, progenitor stem cells, PRIMARY BILIARY-CIRRHOSIS, PROGENITOR CELLS, CYTOKERATIN 7, HEPATOCYTES, EXPRESSION, MARKER
  • Bursa Uludag University Affiliated: Yes

Abstract

INTRODUCTION: Although the immunohistochemical staining with cytokeratin 7 (CK7) is an adjuvant method for identifying various components of the intrahepatic biliary system, the expression of CK7 does not occur in hepatocytes. In the literature, some studies suggest that a group of cells having dual morphologic and immunophenotypic characteristics of bile duct epithelium and hepatocytes, referred to as progenitor stem cells, was stained positive with CK7.