The Effect of Peripherally Administered CDP-Choline in an Acute Inflammatory Pain Model: The Role of alpha 7 Nicotinic Acetylcholine Receptor

GÜRÜN M. S., Parker R., Eisenach J. C., Vincler M.

ANESTHESIA AND ANALGESIA, vol.108, no.5, pp.1680-1687, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 108 Issue: 5
  • Publication Date: 2009
  • Doi Number: 10.1213/ane.0b013e31819dcd08
  • Journal Name: ANESTHESIA AND ANALGESIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1680-1687
  • Bursa Uludag University Affiliated: Yes

Abstract

BACKGROUND: CDP-choline (citicholine; cytidine-5'-diphosphate choline) is an endogenously produced nucleotide which, when injected intracerebroventricularly, exerts an antinociceptive effect in acute pain models mediated by central cholinergic mechanisms and alpha 7 nicotinic acetylcholine receptors (alpha 7nAChR). Previous reports also suggest that the peripheral cholinergic system has an antiinflammatory role mediated by alpha 7nAChRs on macrophages.