THE EFFECTS OF HUMAN AMNIOTIC MEMBRANE AND PERIOSTEAL AUTOGRAFT ON TENDON HEALING: EXPERIMENTAL STUDY IN RABBITS


Ozboluk S., Ozkan Y., Ozturk A., Gul N. Y. , Ozdemir R. M. , Yanik K.

JOURNAL OF HAND SURGERY-EUROPEAN VOLUME, no.4, pp.262-268, 2010 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: Issue: 4
  • Publication Date: 2010
  • Doi Number: 10.1177/1753193409337961
  • Title of Journal : JOURNAL OF HAND SURGERY-EUROPEAN VOLUME
  • Page Numbers: pp.262-268
  • Keywords: flexor tendon injury, adhesion formation, periost, human amniotic membrane, experiment, EARLY ACTIVE MOBILIZATION, FLEXOR TENDON, PERITENDINOUS ADHESIONS, HYALURONIC-ACID, RESTRICTIVE ADHESIONS, REPAIR, SHEATH, INJURY, MOTION, MODEL

Abstract

In this study, the effects of periosteal autograft and human amniotic membrane on tendon healing were compared. Forty-two New Zealand rabbits were divided into three groups. Flexor digitorum fibularis tendons were cut and repaired with a modified Kessler technique and circumferential sutures in all groups. Tendon repair alone was carried out in group 1, tendon repair and application of human amniotic membrane was done in group 2 and tendon repair and application of periosteal autograft was done in group 3. Biomechanical and histopathological examinations were done 2 and 6 weeks postoperatively. Biomechanical examination showed that group 3 was the strongest at weeks 2 and 6. Adhesion, inflammation and new bone formation showed no difference between groups at week 2. However, adhesion formation was found to be less in groups 2 and 3 than group 1 at week 6. The application of periosteal autograft might be useful in repair of tendon injuries.