Mesenteric tissue oxygenation status on the development of necrotizing enterocolitis


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Özkan H. , Çetinkaya M., Dorum B. A. , Köksal F. N.

Turkish Journal Of Pediatrics, vol.5, no.63, pp.811-817, 2021 (Journal Indexed in SCI Expanded)

  • Publication Type: Article / Article
  • Volume: 5 Issue: 63
  • Publication Date: 2021
  • Doi Number: 10.24953/turkjped.2021.05.009
  • Title of Journal : Turkish Journal Of Pediatrics
  • Page Numbers: pp.811-817

Abstract

ABSTRACT

Background. Necrotizing enterocolitis (NEC) is an important cause of morbidity and mortality in preterm

infants. There is limited data about the role of mesenteric oxygenation status during the first enteral feeding.

Therefore, the aim of this study was to determine the mesenteric tissue oxygen saturation values before, during

and after the first enteral feeding and to evaluate the effect of these values on the development of NEC in

preterm infants.

Methods. A total of 105 preterm babies with ≤ 32 gestational weeks were included in this prospective study. The

continuous monitoring of the mesenteric tissue oxygenation status was performed before, during and 3 hours

after the first feeding by near-infrared spectroscopy (NIRS).

Results. The mean gestational week and birth weight of the study group were 28.8±2.1 weeks, and 1215±387 g,

respectively. The first enteral feeding was started at 2.4±1.4 days with breast milk in 85% of infants. A total of 12

infants (11.4%) developed NEC (66% stage II, 34% stage III). The mean mesenteric tissue oxygen saturation levels

of the infants that developed NEC were significantly lower both before and one hour after feeding (56.1±3.4 vs.

34±8.8, and 47.4±3.3 vs 37.8±10.9, respectively) compared with infants that did not develop NEC.

Conclusions. Lower mesenteric tissue oxygenation values measured before, and one hour after enteral feeding

was associated with NEC development. We suggest that lower mesenteric tissue oxygenation during continuous

monitoring of first enteral feeding may be used to predict NEC development during follow-up.

Key words: enteral feeding, near-infrared spectroscopy, necrotizing enterocolitis, NICU, premature.