microRNA-21 Expression is Elevated in Esophageal Adenocarcinoma After Neoadjuvant Chemotherapy


Ilhan-Mutlu A., Tezcan G., Schoppmann S. F. , Preusser M., Spyridoula K., Karanikas G., ...More

CANCER INVESTIGATION, vol.33, no.6, pp.246-250, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 6
  • Publication Date: 2015
  • Doi Number: 10.3109/07357907.2015.1024319
  • Journal Name: CANCER INVESTIGATION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.246-250
  • Keywords: Esophageal cancer, Adenocarcinoma, microRNA-21, microRNA-148a, Neoadjuvant therapy, FDG-PET-CT, PROGNOSTIC-SIGNIFICANCE, CANCER, INVASION, PROLIFERATION, THERAPY
  • Bursa Uludag University Affiliated: Yes

Abstract

We investigated whether microRNA-21 and microRNA-148a are predictive for neoadjuvant treatment in esophageal adenocarcinoma. Thirty-six patients with neoadjuvant therapy and surgical resection were included. FFPE tissue from biopsy and esophagectomy were analyzed using RT-qPCR. Results were correlated to histological tumor regression, histopathological variables, FDG-PET-CT and survival. MicroRNA-21 was significantly higher in esophagectomies than in corresponding biopsies (p = .027). No association of microRNA-21 or micro RNA-148a expression in tissue specimens with other clinical parameters was present. Although no influence of microRNA-21 and microRNA-148a on the response to neoadjuvant therapy was seen, upregulation of micro RNA-21 might represent an escape mechanism of tumor cells.