microRNA-21 Expression is Elevated in Esophageal Adenocarcinoma After Neoadjuvant Chemotherapy
CANCER INVESTIGATION, cilt.33, sa.6, ss.246-250, 2015 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 33 Sayı: 6
- Basım Tarihi: 2015
- Doi Numarası: 10.3109/07357907.2015.1024319
- Dergi Adı: CANCER INVESTIGATION
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.246-250
- Anahtar Kelimeler: Esophageal cancer, Adenocarcinoma, microRNA-21, microRNA-148a, Neoadjuvant therapy, FDG-PET-CT, PROGNOSTIC-SIGNIFICANCE, CANCER, INVASION, PROLIFERATION, THERAPY
- Bursa Uludağ Üniversitesi Adresli: Hayır
Özet
We investigated whether microRNA-21 and microRNA-148a are predictive for neoadjuvant treatment in esophageal adenocarcinoma. Thirty-six patients with neoadjuvant therapy and surgical resection were included. FFPE tissue from biopsy and esophagectomy were analyzed using RT-qPCR. Results were correlated to histological tumor regression, histopathological variables, FDG-PET-CT and survival. MicroRNA-21 was significantly higher in esophagectomies than in corresponding biopsies (p = .027). No association of microRNA-21 or micro RNA-148a expression in tissue specimens with other clinical parameters was present. Although no influence of microRNA-21 and microRNA-148a on the response to neoadjuvant therapy was seen, upregulation of micro RNA-21 might represent an escape mechanism of tumor cells.