New Insights on Neuronal Nicotinic Acetylcholine Receptors as Targets for Pain and Inflammation: A Focus on alpha 7 nAChRs

Bagdas D., GÜRÜN M. S., Flood P., Papke R. L., Damaj M. I.

CURRENT NEUROPHARMACOLOGY, cilt.16, sa.4, ss.415-425, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 16 Sayı: 4
  • Basım Tarihi: 2018
  • Doi Numarası: 10.2174/1570159x15666170818102108
  • Dergi Adı: CURRENT NEUROPHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.415-425
  • Anahtar Kelimeler: alpha 7 nicotinic acetylcholine receptors, nicotine, pain, inflammation, modulators, anti-inflammatory, agonists, POSITIVE ALLOSTERIC MODULATOR, CHOLINERGIC ANTIINFLAMMATORY PATHWAY, GATED ION-CHANNEL, X-RAY-STRUCTURE, NEUROPATHIC PAIN, ANIMAL-MODELS, SPINAL-CORD, BINDING-SITES, HUMAN MONOCYTES, DRUG DISCOVERY
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Background: Nicotine and nicotinic acetylcholine receptors (nAChRs) have been explored for the past three decades as targets for pain control. The aim of this review is to introduce readers particularly to alpha 7 nAChRs in a perspective of pain and its modulation.