Peripheral CD39‐expressing regulatory T cell subsets play an age‐dependent role in the severity of COVID‐19


Çağan E., Şimşek A., Kızmaz M. A., Dombaz F., Tezcan G., Asan A., ...More

6th European Congress of Immunology, İstanbul, Turkey, 1 - 04 September 2021, pp.92

  • Publication Type: Conference Paper / Summary Text
  • City: İstanbul
  • Country: Turkey
  • Page Numbers: pp.92
  • Bursa Uludag University Affiliated: Yes

Abstract

to evaluate the role of CD39‐expressing Treg cell subsets in COVID‐19 immunopathogenesis and their relationship with disease severity. 190 COVID‐19 patients (juvenile and adults)

and 31 volunteers as healthy controls were included in our study. Flow Cytometry analysis was performed with a 10‐color monoclonal antibody panel from peripheral blood samples.

When evaluating CD4+ CD25high CD127low cell percentages in the adult severe and mild cases, a significant increase was observed compared to the control group. Consistently, a

significant increase in severe and mild cases was noted in Treg cell subsets expressing CD39. In juvenile patients, the percentages of CD4+ CD25high CD127low FoxP3 + CD39+ cells

were lower in the 0‐12 age range compared to the 13‐18 age range. To conclude, our study reports significant increases in FoxP3+ CD39+ Treg subsets in adult COVID‐19 patients.

Interestingly, percentages of Tregs co‐expressing FoxP3 and CD39 were positively correlated with increasing age in juvenile patients. Our findings provide a better understanding of

the possible role of Tregs in the immune response mechanism in COVID‐19 cases.

This work was supported by a grant from the Scientific Research Projects Foundation (BAP) of the Bursa Uludag University of Turkey [Project no: OUAP(T)‐2020/6].