Octreotide ameliorates dermal fibrosis in bleomycin-induced scleroderma

Oyucu Orhan S., Tektemur A., Gozel N., Ozercan I. H., Yolbas S., Yildirim A., ...More

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.48, no.4, pp.886-891, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 48 Issue: 4
  • Publication Date: 2018
  • Doi Number: 10.3906/sag-1707-88
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.886-891
  • Bursa Uludag University Affiliated: No

Abstract

Background/aim: Insulin-like growth factor (IGF)-I is a differentiation and growth factor. Antifibrotic action of octreotide has been reported in pulmonary fibrosis. The present study aimed to research the prophylactic and therapeutic potential of octreotide on a bleomycin (BLM)-induced experimental scleroderma model.