Akademik Veri Yönetim Sistemi
6th International Eurasian Conference on Biological and Chemical Sciences (EurasianBioChem 2023), Ankara, Türkiye, 11 - 13 Ekim 2023, cilt.6, ss.140
The application of genomic studies in livestock species aims to comprehend the genetic underpinnings of
specific traits, fortify disease resistance, and elevate product quality and production efficiency. The outcomes
are integrated into animal breeding initiatives, which adopt a methodology aimed at enhancing economic
attributes within livestock through heightened selection efficacy. Given the understanding that yield-related
characteristics result from the additive influence of multiple genes, the identification of Quantitative Trait Loci
(QTL) is employed to delineate chromosomal regions governing these traits. The shared objective of QTL
identification techniques, along with genomic assessment methodologies, is to juxtapose markers and
phenotypic values related to the specific trait. The intricacy inherent in the desired attributes has spurred the
development of genomic selection methodology, which is rooted in predictive approaches rather than empirical
testing. The utilization of selection strategies, coupled with genotyping for production-related traits and marker
identification, has accelerated the pace of genetic advancement. Given that numerous genes contribute to the
manifestation of most economic traits, the mere identification of a limited subset of these genes through DNA
markers will merely account for a fraction of the overall genetic variance. Furthermore, individual genes are
inclined to exert modest effects, necessitating a substantial volume of data to estimate their impact accurately.
This challenge becomes more pronounced when utilizing a haplotype of markers to track QTL, as the need to
estimate numerous haplotype effects arises. While the markers employed for Marker-Assisted Selection
(MAS) may be associated with QTL, they might also exist in linkage equilibrium rather than linkage
disequilibrium (LD) with the QTL. In instances of LD, it is plausible that either the QTL or the marker itself
could indeed function as the QTL. In this work, our aim was to compare these methodologies, evaluating their
efficacy in the context of pivotal selection practices integral to livestock breeding.