Fluconazole treatment of neonates and infants with severe fungal infections.


Gurpinar A., Balkan E., Kilic N. , Kiristioglu İ. , Avsar I., Dogruyol H.

The Journal of international medical research, vol.25, no.4, pp.214-8, 1997 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 4
  • Publication Date: 1997
  • Doi Number: 10.1177/030006059702500408
  • Title of Journal : The Journal of international medical research
  • Page Numbers: pp.214-8

Abstract

A total of 24 neonates and infants, aged from 2 days to 10 months, received treatment with intravenous fluconazole for microbiologically documented or presumed fungal infection. The mean fluconazole dosage was 6 mg/kg/day (range 2 -16 mg/kg/day) and the mean duration of therapy was 25 days (range 5 - 72 days). Efficacy was evaluated in neonates with proven fungal infections, as documented by the presence of pathogen at baseline. A positive clinical response was achieved in 23 of the 24 clinically evaluable patients (96%); eradication of the fungal organism was also achieved in 23 of the 24 evaluable patients (96%). Adverse events occurred in two patients (8%) but therapy was not discontinued in either patient. The present results confirm the efficacy and safety of fluconazole in the treatment of neonates and infants with severe fungal infections.