Trends of bloodstream infections in a university hospital during a 12-year period

Tüzemen N. Ü., Payaslıoğlu A. M., Özakın C., Ener B., Akalın E. H.

POLISH JOURNAL OF MICROBIOLOGY, cilt.1, sa.1, ss.1-2, 2022 (SCI-Expanded)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 1 Sayı: 1
  • Basım Tarihi: 2022
  • Dergi Adı: POLISH JOURNAL OF MICROBIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, Food Science & Technology Abstracts, MEDLINE, Directory of Open Access Journals
  • Sayfa Sayıları: ss.1-2
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

This study aims to investigate trends in bloodstream infections and their antimicrobial

susceptibility profiles over a 12-year period in our hospital. This retrospective study

was carried out in the Bursa Uludag University Hospital, Turkey, during 2008-2019.

Blood cultures from patients were performed by BACTEC System. Isolates were

identified by Phoenix System until 2018, and “matrix-assisted laser desorption

ionization time-of-flight mass spectrometry” (MALDI-TOF MS) in 2019. Antibiotic

susceptibility testing was performed by Phoenix System. Patient data were obtained

from the BD EpiCenter data management system. Escherichia coli was found to be the

most common Gram-negative (11.6%), and coagulase-negative staphylococci were the

most common Gram-positive (10.1%) monomicrobial growth. Overall, there was a

significant increase in rates of extended-spectrum β-lactamase positive E. coli (p:

0.014) and Klebsiella pneumonia (p<0.001), carbapenem-resistant E. coli (p<0.001),

and K. pneumoniae (p<0.001) and colistin-resistant K. pneumoniae (p<0.001) and

Acinetobacter baumannii (p<0.001) over 12 years. Carbapenem and colistin resistance

have increased dramatically in recent years. We believe that regular monitoring of the

distribution of pathogens and antibiotic susceptibility profiles, especially in intensive

care units, can contribute to evidence for the increase in resistant microorganisms and

help prevent their spread with antimicrobial stewardship and infection control policies.