Efficient and chemoselective alkyl bromoacetate-Zn mediated transesterification method

Coskun N., Er M.

TETRAHEDRON, vol.59, no.19, pp.3481-3485, 2003 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 59 Issue: 19
  • Publication Date: 2003
  • Doi Number: 10.1016/s0040-4020(03)00472-1
  • Journal Name: TETRAHEDRON
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.3481-3485
  • Keywords: chemoselective transesterification, Reformatsky reagent, IMIDAZOLINE 3-OXIDES, DIASTEREOSELECTIVE ADDITION, REGIO
  • Bursa Uludag University Affiliated: Yes


Alkyl bromoacetates were shown to be versatile transesterification reagents. Isoxazoles underwent chemoselective transesterification when treated with alkyl bromoacetate-Zn in THF at reflux. A suggested mechanism of the new reaction was discussed. (C) 2003 Elsevier Science Ltd. All rights reserved.