Enhanced cytotoxic activity of doxorubicin through the inhibition of autophagy in triple negative breast cancer cell line

Aydinlik, Seyma; Erkisa, Merve; Cevatemre, Buse; SARIMAHMUT, MEHMET; DERE, EGEMEN; ARI, FERDA; Ulukaya, Engin

doi:10.1016/j.bbagen.2016.11.013

Enhanced cytotoxic activity of doxorubicin through the inhibition of autophagy in triple negative breast cancer cell line

Aydinlik S., Erkisa M., Cevatemre B., SARIMAHMUT M., DERE E., ARI F., ...More

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, vol.1861, no.2, pp.49-57, 2017 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 1861 Issue: 2
Publication Date: 2017
Doi Number: 10.1016/j.bbagen.2016.11.013
Journal Name: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.49-57
Keywords: Autophagy, Breast cancer, Necroptosis, Drug resistance, Synergism, DOUBLE-EDGED-SWORD, INDUCED APOPTOSIS, PROTECTIVE AUTOPHAGY, DEATH, ACTIVATION, INDUCTION, CYCLE, HYDROXYCHLOROQUINE, MACROAUTOPHAGY, TUMORIGENESIS
Bursa Uludag University Affiliated: Yes

Abstract

Background: The outcome of triple negative breast cancer is still poor and requires improvement with better therapy options. Autophagy has recently been shown to play a role in anticancer drug resistance. Therefore, we investigated if the effectiveness of doxorubicin was augmented by the inhibition of autophagy.