Enhanced cytotoxic activity of doxorubicin through the inhibition of autophagy in triple negative breast cancer cell line


Aydinlik S., Erkisa M., Cevatemre B., SARIMAHMUT M. , DERE E. , ARI F. , ...More

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, vol.1861, no.2, pp.49-57, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 1861 Issue: 2
  • Publication Date: 2017
  • Doi Number: 10.1016/j.bbagen.2016.11.013
  • Title of Journal : BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
  • Page Numbers: pp.49-57
  • Keywords: Autophagy, Breast cancer, Necroptosis, Drug resistance, Synergism, DOUBLE-EDGED-SWORD, INDUCED APOPTOSIS, PROTECTIVE AUTOPHAGY, DEATH, ACTIVATION, INDUCTION, CYCLE, HYDROXYCHLOROQUINE, MACROAUTOPHAGY, TUMORIGENESIS

Abstract

Background: The outcome of triple negative breast cancer is still poor and requires improvement with better therapy options. Autophagy has recently been shown to play a role in anticancer drug resistance. Therefore, we investigated if the effectiveness of doxorubicin was augmented by the inhibition of autophagy.