Enhanced cytotoxic activity of doxorubicin through the inhibition of autophagy in triple negative breast cancer cell line

Aydinlik, Seyma; Erkisa, Merve; Cevatemre, Buse; SARIMAHMUT, MEHMET; DERE, EGEMEN; ARI, FERDA; Ulukaya, Engin

doi:10.1016/j.bbagen.2016.11.013

Enhanced cytotoxic activity of doxorubicin through the inhibition of autophagy in triple negative breast cancer cell line

Aydinlik S., Erkisa M., Cevatemre B., SARIMAHMUT M., DERE E., ARI F., ...Daha Fazla

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, cilt.1861, sa.2, ss.49-57, 2017 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 1861 Sayı: 2
Basım Tarihi: 2017
Doi Numarası: 10.1016/j.bbagen.2016.11.013
Dergi Adı: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.49-57
Anahtar Kelimeler: Autophagy, Breast cancer, Necroptosis, Drug resistance, Synergism, DOUBLE-EDGED-SWORD, INDUCED APOPTOSIS, PROTECTIVE AUTOPHAGY, DEATH, ACTIVATION, INDUCTION, CYCLE, HYDROXYCHLOROQUINE, MACROAUTOPHAGY, TUMORIGENESIS
Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Background: The outcome of triple negative breast cancer is still poor and requires improvement with better therapy options. Autophagy has recently been shown to play a role in anticancer drug resistance. Therefore, we investigated if the effectiveness of doxorubicin was augmented by the inhibition of autophagy.