Investigation of TNF-alpha gene (G308A) and GSTP1 gene (Ile105Val) polymorphisms in Turkish patients with retinopathy of prematurity


Ture M., YILDIZ M. , Karkucak M., Gulten E. T. , SIĞIRLI D. , ÖZMEN A. T. , ...More

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.45, no.1, pp.164-169, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 1
  • Publication Date: 2015
  • Doi Number: 10.3906/sag-1307-94
  • Title of Journal : TURKISH JOURNAL OF MEDICAL SCIENCES
  • Page Numbers: pp.164-169
  • Keywords: TNF-alpha, GSTP1, gene polymorphism, retinopathy of prematurity, TUMOR-NECROSIS-FACTOR, NORRIE-DISEASE GENE, ENDOTHELIAL GROWTH-FACTOR, BIRTH-WEIGHT INFANTS, PROMOTER REGION, DIABETIC-RETINOPATHY, MISSENSE MUTATIONS, ASSOCIATION, SUSCEPTIBILITY, POPULATION

Abstract

Background/aim: Retinopathy of prematurity (ROP) is one of the most frequent causes of blindness in newborn babies. Currently, its etiology is not fully understood. In this study we aimed to investigate the correlation between a patient group with ROP and a control group in terms of the tumor necrosis factor- alpha (TNF-alpha) (G308A) gene and glutathione-S-transferase P1 (GSTP1) (Ile105Val) gene polymorphism.