The in vivo and in vitro comparative nephrotoxicity of cefazolin and gentamicin


Yilmaz O., Cabalar M., Ozbilgin S.

VETERINARY AND HUMAN TOXICOLOGY, vol.41, no.4, pp.222-225, 1999 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 41 Issue: 4
  • Publication Date: 1999
  • Title of Journal : VETERINARY AND HUMAN TOXICOLOGY
  • Page Numbers: pp.222-225

Abstract

Biochemical, histopathological and cell culture evaluations compared the nephrotoxicity of cefazolin with that of gentamicin. New Zealand rabbits were dosed with 250 mg cefazolin/animal im twice daily, 3 mg gentamicin/kg im twice daily, or 0.9% NaCl solution for 10 d. The rabbits in drug-treated groups had necrosis of proximal kidney tubules and elevated urinary-gamma glutamyl transferase (uGGT) levels. The results of the histopathological examinations, uGGT analyses and effects in cell culture indicated the nephrotoxicities of both antibiotics were similar.