High-content cytometry and transcriptomic biomarker profiling of human B-cell activation

Hennig C., Ilginus C., Boztug K., Skokowa J., Marodi L., Szaflarska A., ...More

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol.133, no.1, pp.172-190, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 133 Issue: 1
  • Publication Date: 2014
  • Doi Number: 10.1016/j.jaci.2013.06.047
  • Journal Name: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.172-190
  • Keywords: Primary immunodeficiency, primary antibody deficiency, B-cell immunology, chip cytometry, AUTOSOMAL RECESSIVE FORM, ATAXIA-TELANGIECTASIA, DEFICIENCY, IMMUNODEFICIENCIES, EXPRESSION, MUTATIONS, PATHWAY, AID, ATM
  • Bursa Uludag University Affiliated: Yes

Abstract

Background: Primary antibody deficiencies represent the most prevalent, although very heterogeneous, group of inborn immunodeficiencies, with a puzzling complexity of cellular and molecular processes involved in disease pathogenesis.