Akademik Veri Yönetim Sistemi
Journal of Porous Materials, 2025 (SCI-Expanded, Scopus)
In this study, it was aimed to prepare a drug delivery system that combines pH sensitivity and magnetic targetability, as well as controlled drug release by changing the loading capacity, in a single structure. Magnetically targetable hollow mesoporous silica nanocomposite (MT-HMSN) was synthesized by using cationic surfactant based selective etching method and investigated as drug carrier for the loading and release of anticancer drug Doxorubicin (DOX). Remarkably high adsorption capacities were achieved with 25, 50 and 75 mg/L DOX loading (50.32, 85.18 and 103.15 mg/g for MT-HMSN/DOX-25/50/75, respectively). After being followed by in vitro release study during 48 h, MT-HMSN/DOX-25 had the highest release percentages with 29.27% and 83.46% at pH 7.4 and 5.5, respectively, while MT-HMSN/DOX-75 exhibits the lowest release performances with 16.53% and 38.73% at these pH values, respectively. In this context, MT-HMSN could increase the drug release in cancerous regions where it is magnetically targeted depending on pH activation. Moreover, through the increase in capacity, the blocked situation in the porous structure causes difficulty in diffusion at the time of release, and thus, without the need for any functional agent or gatekeeper, the drug release rate can be delayed by loading only a high amount of drug, while it can be accelerated at low loadings. Korsmeyer-Peppas model based on Fickian diffusion effectively explained the release behavior of DOX from MT-HMSN/DOX in both acidic and neutral pH media with the correlation coefficient greater than 0.98, supporting that MT-HMSN can also exhibit a controlled release depending on the loading quantity.