CDP-choline and its endogenous metabolites, cytidine and choline, promote the nerve regeneration and improve the functional recovery of injured rat sciatic nerves


Aslan E., KOCAELİ H. , BEKAR A. , TOLUNAY Ş. , ULUS İ. H.

NEUROLOGICAL RESEARCH, vol.33, no.7, pp.766-773, 2011 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 7
  • Publication Date: 2011
  • Doi Number: 10.1179/1743132811y.0000000004
  • Title of Journal : NEUROLOGICAL RESEARCH
  • Page Numbers: pp.766-773

Abstract

Objective: Topical cytidine-5'-diphosphocholine (CDP-choline) has been shown to improve the functional recovery and promote the nerve regeneration of injured sciatic nerves in rats. The aims of this study were to test whether CDP-choline was effective at promoting nerve healing when the surgery to repair an injury was delayed and to determine whether the cytidine and/or the choline moieties of CDP-choline contribute to its beneficial actions.