We consider two distinct classes of Yukawa unified supersymmetric SO(10) models with non-universal and universal soft supersymmetry breaking (SSB) gaugino masses at M-GUT. In both cases, we assume that the third family SSB sfermion masses at M-GUT are different from the corresponding sfermion masses of the first two families (which are equal). For the SO(10) model with essentially arbitrary (non-universal) gaugino masses at M-GUT, it is shown that t-b-tau Yukawa coupling unification is compatible, among other things, with the 125 GeV Higgs boson mass, the WMAP relic dark matter density, and with the resolution of the apparent muon g-2 anomaly. The colored sparticles in this case all turn out to be quite heavy, of order 5TeV or more, but the sleptons (smuon and stau) can be very light, of order 200 GeV or so. For the SO(10) model with universal gaugino masses and NUHM2 boundary conditions, the muon g - 2 anomaly cannot be resolved. However, the gluino in this class of models is not too heavy, less than or similar to 3TeV, and therefore may be found at the LHC.