Giving uridine and/or docosahexaenoic acid orally to rat dams during gestation and nursing increases synaptic elements in brains of weanling pups
Developmental Neuroscience, cilt.31, sa.3, ss.181-192, 2009 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 31 Sayı: 3
- Basım Tarihi: 2009
- Doi Numarası: 10.1159/000193394
- Dergi Adı: Developmental Neuroscience
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.181-192
- Anahtar Kelimeler: Development, Docosahexaenoic acid, Uridine, Membrane phosphatides, Dendritic spines, Synaptic proteins, Synaptogenesis, Infant nutrition, POLYUNSATURATED FATTY-ACIDS, NUCLEOSIDE TRANSPORTER FAMILY, CDP-CHOLINE, ARACHIDONIC-ACID, DENDRITIC SPINES, BREAST-MILK, PHEOCHROMOCYTOMA CELLS, NEURITE OUTGROWTH, FETAL-DEVELOPMENT, DIETARY CHOLINE
- Bursa Uludağ Üniversitesi Adresli: Evet
Özet
Developing neurons synthesize substantial quantities of membrane phospholipids in producing new synapses. We investigated the effects of maternal uridine (as uridine-5′-monophosphate) and docosahexaenoic acid supplementation on pups' brain phospholipids, synaptic proteins and dendritic spine densities. Dams consumed neither, 1 or both compounds for 10 days before parturition and 20 days while nursing. By day 21, brains of weanlings receiving both exhibited significant increases in membrane phosphatides, various pre- and postsynaptic proteins (synapsin-1, mGluR1, PSD-95), and in hippocampal dendritic spine densities. Administering these phosphatide precursors to lactating mothers or infants could be useful for treating developmental disorders characterized by deficient synapses. Copyright © 2009 S. Karger AG, Basel.