Sutureless vascular anastomoses by N-butyl-2 cyanoacrylate adhesive: An experimental animal study


Saba D., Yilmaz M., Yavuz H., Noyan S. , Avci B. , Ercan A., ...More

European Surgical Research, vol.39, no.4, pp.239-244, 2007 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 4
  • Publication Date: 2007
  • Doi Number: 10.1159/000101893
  • Title of Journal : European Surgical Research
  • Page Numbers: pp.239-244
  • Keywords: sutureless anastomoses, polytetrafluoroethylene, N-butyl-2-cyanoacrylate, OCTYLCYANOACRYLATE TISSUE ADHESIVE, MICROVASCULAR ANASTOMOSIS, CLINICAL-APPLICATIONS, SURGERY, CLOSURE, GLUE, ARTERIES

Abstract

Background: The purpose of this animal study was to find out whether sutureless anastomoses using N-butyl-2-cyanoacrylate were effective in the suppression of neointimal hyperplasia or not. Material and Methods: Ten male adult mongrel dogs were used in this animal study. The animals were randomly divided into a control group (n = 5) and a study group (n = 5). The study group underwent sutureless anastomoses using N-buthyl-2-cyanoacrylate adhesive. Infrarenal aortoaortic graft was interposed using polytetrafluoroethylene. Results: In the study group, the mean intimal thickness at the proximal anastomosis was 27.4 ± 1.94 μm and 27.4 ± 1.51 μm at the distal anastomosis. In the control group, the mean intimal thickness was 138.4 ± 5.02 μm at the proximal anastomosis and 67.6 ± 6.42 μm at the distal anastomosis. Intimal thickness at the proximal and distal anastomoses in the control group was significantly (p < 0.001) greater than in the study group. Also, perianastomotic inflammation was more obvious in the control group compared to the study group (p < 0.01). Conclusion: Sutureless anastomoses using with N-butyl-2-cyanoacrylate adhesive might be a good alternative to conventional suture technique. Copyright © 2007 S. Karger AG.