Epstein-Barr virus infection in children with renal transplantation: 17 years experience at a single center.


Comak E., Akman S., Ongut G., Colak D., Koyun M., Dogan C., ...More

Renal failure, vol.36, pp.760-6, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 36
  • Publication Date: 2014
  • Doi Number: 10.3109/0886022x.2014.890861
  • Journal Name: Renal failure
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.760-6
  • Keywords: Children, Epstein-Barr virus infection, renal transplantation, POSTTRANSPLANT LYMPHOPROLIFERATIVE DISORDER, POLYMERASE-CHAIN-REACTION, VIRAL LOAD, PERIPHERAL-BLOOD, EBV PCR, RECIPIENTS, RISK, DIAGNOSIS, DISEASE, CELLS
  • Bursa Uludag University Affiliated: Yes

Abstract

Objectives: The aim of this study was to detect the frequency, time of occurrence, management and outcome of Epstein-Barr virus (EBV) infection and related complications in pediatric renal transplant recipients. Methods: Pediatric renal allograft recipients transplanted between August 1994 and December 2011 at our hospital was evaluated retrospectively. The patients were divided into two groups; Groups 1 and 2 were composed of patients transplanted before and after November 2007, respectively, when plasma EBV DNA levels were periodically measured. Results: The study included 166 children, 89 (53.6%) boys, with a mean age of 12.2 +/- 3.8 years. Prior to transplantation, 144 patients (86.7%) were EBV seropositive. Within a median follow-up period of 36 months, 11 of 22 seronegative children (50%) developed primary EBV infection. EBV reactivation was observed in 23 of 144 children (15.9%). Two patients with primary infection developed post-transplant lymphoproliferative disorder, one of whom died. Elevated serum creatinine levels or graft loss were not observed in any patient with EBV reactivation. Conclusions: EBV DNA monitoring by PCR in high-risk pediatric renal transplant recipients will provide early diagnosis and treatment of EBV infections.