Muscimol injection into the lateral hypothalamus inhibits the hypotension and bradycardia caused by somato-visceral nociception

Goktalay G., Levendusky M., Millington W.

BRAIN RESEARCH, cilt.1029, sa.1, ss.124-130, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 1029 Sayı: 1
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1016/j.brainres.2004.09.029
  • Dergi Adı: BRAIN RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.124-130
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

This study investigated whether the lateral hypothalamus (LH) contributes to the depressor response evoked by somato-visceral nociception. Lidocame (2%; 0.1, 0.3 or 1.0 mul) or muscimol (0.34 nmol; 0.5 mul) was microinjected into the rostral LH of halothane-anesthetized rats bilaterally and somato-visceral nociception was induced 2 min later by injecting 5% acetic acid (0.5 ml) intraperitoneally. Lidocaine and muscimol inhibited the hypotension and bradycardia caused by somato-visceral nociception significantly without affecting cardiovascular function in normotensive animals. (C) 2004 Elsevier B.V. All rights reserved.