Molecular Characterization of Drug Resistance in Hepatitis B Viruses Isolated from Patients with Chronical Infection in Turkey

Asan, Ali; SAYAN, MURAT; AKHAN, SILA; Koruk, Suda; AYGEN, BİLGEHAN; SIRMATEL, FATMA; Eraksoy, Haluk; Tuna, Nazan; Kose, Sukran; Kaya, Ali; Tulek, Necla; DEMİR, NAZLIM; Mistik, Resit; Ormen, Bahar; Korkmaz, Fatime; Yildirmak, Taner; URAL, ONUR; Aydin, Mehtap; TURGUT, HÜSEYİN; Gunal, Ozgur; DEMİRTÜRK, NEŞE

doi:10.5812/hepatmon.12472

Molecular Characterization of Drug Resistance in Hepatitis B Viruses Isolated from Patients with Chronical Infection in Turkey

Asan A., SAYAN M., AKHAN S., Koruk S. T., AYGEN B., SIRMATEL F., ...Daha Fazla

HEPATITIS MONTHLY, cilt.18, sa.1, 2018 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 18 Sayı: 1
Basım Tarihi: 2018
Doi Numarası: 10.5812/hepatmon.12472
Dergi Adı: HEPATITIS MONTHLY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Background: Hepatitis B virus (HBV) has a high mutation rate due to its unusual replication strategy leading to the production of a large number of virions with single and double mutations. The mutations, in turn, are associated with the development of drug resistance to nucleos(t)ide analogs (NUCs) in patients before and during NUCs therapy.