Synthesis of new anthraquinone compounds and evaluation of their considerable xanthine oxidase inhibitory activities

Parladı U., Yılmaz Ü., Noma S. A. A., Ateş B., Küçükbay H.

ARKIVOC, vol.2022, no.9, pp.158-167, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 2022 Issue: 9
  • Publication Date: 2022
  • Doi Number: 10.24820/ark.5550190.p011.810
  • Journal Name: ARKIVOC
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Directory of Open Access Journals
  • Page Numbers: pp.158-167
  • Keywords: Anthraquinone derivative, quinizarin, danthron, xanthine oxidase, inhibition, URIC-ACID, DERIVATIVES, QUINIZARIN, DYES, SENSITIZER
  • Bursa Uludag University Affiliated: Yes


A series of anthraquinone derivatives (1-11) was prepared using alkyl halides, quinizarin, and danthron. The structural analysis of new compounds was carried out by 1H, 13C NMR, IR, and UV-Vis spectroscopic techniques. Xanthine oxidase inhibitory activities of compounds were measured using allopurinol as a standard. Inhibition abilities were identified by measuring the uric acid formation at 294 nm at 37 °C. According to the IC50 values of the compounds, it was observed that all the compounds in the group had higher inhibition values than allopurinol.