Synthesis of new anthraquinone compounds and evaluation of their considerable xanthine oxidase inhibitory activities

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Parladı U., Yılmaz Ü., Noma S. A. A., Ateş B., Küçükbay H.

ARKIVOC, vol.2022, no.9, pp.158-167, 2022 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 2022 Issue: 9
• Publication Date: 2022
• Doi Number: 10.24820/ark.5550190.p011.810
• Journal Name: ARKIVOC
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Directory of Open Access Journals
• Page Numbers: pp.158-167
• Keywords: Anthraquinone derivative, quinizarin, danthron, xanthine oxidase, inhibition, URIC-ACID, DERIVATIVES, QUINIZARIN, DYES, SENSITIZER
• Bursa Uludag University Affiliated: Yes

Abstract

A series of anthraquinone derivatives (1-11) was prepared using alkyl halides, quinizarin, and danthron. The structural analysis of new compounds was carried out by 1H, 13C NMR, IR, and UV-Vis spectroscopic techniques. Xanthine oxidase inhibitory activities of compounds were measured using allopurinol as a standard. Inhibition abilities were identified by measuring the uric acid formation at 294 nm at 37 °C. According to the IC50 values of the compounds, it was observed that all the compounds in the group had higher inhibition values than allopurinol.