Evaluation of biocompatibility of fibroin-based electrospun nanofibrous mats for medical applications


Safak S., Düzyer Gebizli Ş., Karaca E.

INDUSTRIA TEXTILA, vol.67, pp.3-9, 2016 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 67
  • Publication Date: 2016
  • Journal Name: INDUSTRIA TEXTILA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.3-9
  • Keywords: electrospinning, nanofiber, silk fibroin, biocompatibility, DRUG-DELIVERY, IN-VITRO, SILK, FIBROBLASTS, SCAFFOLDS, VIVO
  • Bursa Uludag University Affiliated: Yes

Abstract

In this study, Bombyx Mori silk fibroin and poly(vinyl alcohol) polymers were used. Blend solutions in two different ratios were prepared and solution parameters were determined by pH, conductivity and viscosity measurements. Silk fibroin/poly(vinyl alcohol) nanofibrous mats were produced by electrospinning process. The morphological characterization of electrospun nanofibers was examined by scanning electron microscope. Biocompatibility of the silk fibroin/poly(vinyl alcohol) nanofibrous mats was investigated by cytotoxicity, sensitization and irritation tests. As a result, both of the silk fibroin/poly(vinyl alcohol) nanofibrous mats were evaluated as noncytotoxic, nonirritative and sensitive materials.