Evaluation of biocompatibility of fibroin-based electrospun nanofibrous mats for medical applications

Safak S., Düzyer Gebizli Ş., Karaca E.

INDUSTRIA TEXTILA, cilt.67, ss.3-9, 2016 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 67
  • Basım Tarihi: 2016
  • Dergi Adı: INDUSTRIA TEXTILA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.3-9
  • Anahtar Kelimeler: electrospinning, nanofiber, silk fibroin, biocompatibility, DRUG-DELIVERY, IN-VITRO, SILK, FIBROBLASTS, SCAFFOLDS, VIVO
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

In this study, Bombyx Mori silk fibroin and poly(vinyl alcohol) polymers were used. Blend solutions in two different ratios were prepared and solution parameters were determined by pH, conductivity and viscosity measurements. Silk fibroin/poly(vinyl alcohol) nanofibrous mats were produced by electrospinning process. The morphological characterization of electrospun nanofibers was examined by scanning electron microscope. Biocompatibility of the silk fibroin/poly(vinyl alcohol) nanofibrous mats was investigated by cytotoxicity, sensitization and irritation tests. As a result, both of the silk fibroin/poly(vinyl alcohol) nanofibrous mats were evaluated as noncytotoxic, nonirritative and sensitive materials.